Cells play an important role in both pathological studies of stroke and in the development of therapies. In pathological studies, on the one hand, we provide a preliminary understanding of the pathological mechanisms of stroke by establishing different stroke models based on brain cells. On the other hand, we elaborate the role of stroke on different cells through the study of different cells in in vivo models. In therapeutic development, stem cell-based stroke therapy has been shown to be effective in alleviating the damage caused by stroke.
Different Types of Cell Banks for Stroke Research
Stem Cell Bank
Ace Neuroscience has an extensive cell bank covering the types of stem cells that can be used to develop stem cell therapy and other studies, including but not limited to adult tissue-derived stem cells, adipose tissue-derived MSCs, breastmilk-derived stem cells, and menstrual blood stem cells. Based on our stem cell bank, our expert scientists will select the most suitable type of stem cell for you based on your experiment.
Brain Cell Bank
To some extent, the pathological state of the brain after a stroke can be reflected by in vitro studies of different brain cells. Ace Neuroscience provides neurons, epithelial cells, and neuroglia, such as astrocytes, oligodendrocytes, and microglia.
- Glial cells mediate multiple physiological and pathological responses to the stroke process, including oxidative stress, inflammatory responses, neuroprotection, and neurotrophic effects.
- Epithelial cells can measure vascular changes after stroke.
- Neurons play a vital role in the brain. The target of many stroke therapies is by protecting or restoring neuronal function.
Different Sources of Cell Banks for Stroke Research
Cell banks from different sources play different roles at different stages of stroke research. Therefore, it is important for stroke research to establish a cell bank covering different mammalian, insect, microbial, and other cells.
Mammalian, Insect & Other Cell Banks
Ace Neuroscience has a variety of mammalian, insect, avian, and other types of cells and has constructed cell banks accordingly. We rigorously test the viability of the cells after banking, sterility, and mycoplasma. For cell expansion for testing, we provide in vivo adventitious agent tests, MAP and HAP tests, TEM tests, bovine and porcine adventitious agent tests, and other relevant tests.
- Our microbial contamination assays include bacteriostatic and fungistasis, sterility, mycoplasma, spiroplasma, and mycobacterium.
- We test cells for virological contamination by transmission electron microscopy, reverse transcriptase PCR assay, retroviral infectivity assays, in vitro and in vivo adventitious virus tests, PCR and in vitro assays for specific viruses, and other assays.
- We perform identification and genetic stability analysis of cell lines by isoenzyme analysis and karyology, DNA barcoding or other DNA fingerprinting methods, copy number determination, restriction endonuclease analysis, DNA / RNA sequencing, and other methods.
Ace Neuroscience has extensive experience in manufacturing microbial cell banks. We always hold ourselves to the highest standards and strictly control every step of the manufacturing and shipping process to ensure the quality and biosafety of our cells.
- For the production and release of cell bank, we perform strict bacteriophage, viability, purity, and identification tests to ensure that the cells are free of contamination.
- We further perform tests related to the retention of selectable markers, retention of recombinant structures, sequencing, restriction endonuclease analysis, copy number determination, and other relevant tests on microbial cells to provide comprehensive information on the cells and ensure the safety of the cell bank.
Cell Bank Storage, Retrieval & Distribution
Storage Ace Neuroscience strictly manages and classifies cells. We store cells at -70°C or in liquid nitrogen.
Retrieval Ace Neuroscience assigns a unique identification number to each vial of cells for fast and accurate retrieval.
Distribution Ace Neuroscience transfers the removed cells to a special transport container, which is equipped with a recording device to monitor the cell transport environment.
