Biofilm is a complex, multi-dimensional spatial structure composed of microorganisms and their extracellular polymers adhered to the surface of living or non-living bodies, and is ubiquitous in nature. Biofilms are increasingly detected in patients with infectious diseases or in animal models. The relationship between the formation of biofilm and infectious diseases and its role in the occurrence, development and prognosis of diseases have become a hot research topic in recent years. At present, we provide computational biology-assisted research on biofilm technology to help customers complete biofilm-related research.Our ServicesComputational biology is a branch of biology, which refers to the development and application of data analysis and theoretical methods, mathematical modeling and computer simulation technology, etc., a method for biological research. We provide one-stop biofilm system computation service of biofilm system. We offer a variety of methods and equipment to choose from to meet your research needs.
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IntroductionAging is a biological process that occurs in each of us as individuals and is accompanied by a variety of changes. At the molecular level, DNA methylation occurs, a process in which a methyl group is covalently bonded at the cytosine 5 carbon position of a genomic CpG dinucleotide, and the association between DNA methylation and aging has been extensively studied and their close correlation has been found.DNA methylation is an epigenetic modification that plays a key role in many aging-related biological processes. Based on this, we can use DNA methylation analysis for related studies, such as age prediction, disease risk prediction, and aging mechanism exploration.Our ServicesWe have a unique DNA methylation technology and research system, can explore aging and age-related disease research for DNA methylation analysis, providing services including age prediction, disease biomarker discovery, evaluation of longevity interventions, etc. DNA Methylation Dynamics AnalysisDNA methylation pattern changes with age and has an important impact on human longevity and related disease development. Therefore, it is very meaningful to study DNA methylation dynamics in aging process. Age Prediction Based on DNA MethylationAt present, DNA methylation may be the most potential age predictor, measuring the age of DNA methylation can be used in individual age and health detection, disease prediction, and longevity research. DNA Methylation Age Acceleration ResearchWhen an individual's DNA methylation age is greater than the actual age, this means that the individual is in an age acceleration state, and which may be associated with many aging manifestations, disease development, and even death. Age-Related Diseases DNA Methylation Biomarker DiscoveryDNA methylation changes are involved in various processes of age-related disease development, affecting the function of key genes, and perhaps by using its changes as biomarkers we can identify or monitor pathological processes. Longevity Interventions Evaluation Using DNA MethylationA number of interventions may be able to prevent age-related diseases and extend lifespan, including dietary, pharmacological and genetic, and the effects of interventions to delay aging and increase longevity can be assessed based on age-related DNA methylation changes.
Quantifying the resulting mechanical parameters is critical for clarifying the mechanical consequences caused by the changed cell wall composition. We are committed to providing our customers with services for the characterization of mechanical properties of plant cell walls and submitting detailed and scientific experimental reports to customers.Background of mechanical properties of cell wall analysis servicesThe cell wall has long been of interest to researchers because of its unique mechanical properties. It has both the mechanical stability to support plant morphology and the ability to allow cells to expand for growth without rupture. The non-linear way it responds to stress can even actively change to suit the plant's growth needs at different stages. These properties provide the inspiration for the production of polymer materials with improved strength and ductility.A number of different methods have been used to measure the stiffness of plant tissues, such as stretching separated tissues directly with an extensometer and manipulating turgor pressure with a pressure probe followed by measuring the resulting deformation. However, these techniques are destructive to the sample and cannot be used to measure the mechanical properties of living tissues. In recent years, advances in instrumentation and technology in the field of biophysical analysis have facilitated the study of the mechanical properties of plant cell walls. New techniques such as atomic force microscopy (AFM) and microindentation have opened up new possibilities for measuring the mechanical properties of biological systems in vivo.
Turgor pressure measurement servicesTurgor pressure, also known as hydrostatic pressure, is the pressure on the cell wall generated by the expansion of a plant cell due to the volume of water absorbed. Turgor pressure is of physiological importance to plant growth. Not only does it maintain cellular tension and keep the plant in its natural posture, it also regulates the opening and closing of stomata. The growth of plant cells is thought to be the result of a finely tuned interaction between turgor pressure (aimed at increasing volume) and rigid cell wall (aimed at limiting turgor-driven expansion). In order to describe growth at a mechanical level, it is necessary to quantify the turgor pressure and the elastic properties of the cell wall.Over the years, the correlation between cell wall elasticity, turgor and growth has remained unclear, despite the rapid development of techniques to characterize the mechanical properties of plant cells that have contributed in elucidating how growth is controlled and coordinated. A variety of techniques have been established to estimate turgor, including pressure probes, ball tonometry and techniques based on indentation experiments.
Biofilm Construction ServicesBacterial biofilm formation is a complex developmental process involving multiple stages, including migration and initial attachment, EPS production and irreversible attachment, maturation, disruption, and cell dispersion. In most environments, the mechanism of infection and pathogenesis is a continuous interaction between the host and the microorganism, as well as between the microorganisms themselves. These interactions can influence and determine the fate of infection, and they are complex and dynamic, which makes it difficult to study them in a relevant manner in in vitro models. The success of in vitro models and their limitations, in particular their inability to replicate the host environment, have led to the rapid development of multiple in vivo models.
Telomere length is highly heterogeneous and varies with cell type, age, and individual. Most current measurements of telomere length use the average of cell populations. However, it is worth noting that methods to quantify the length of individual telomeres can provide valuable information about telomere length distribution.Telomere Length Measurement in Single Cells Extremely short telomeres are usually the cause of age-related pathology. The longest telomeres are markers of the adult stem cell compartment. These findings all suggest that individual telomere length heterogeneity plays a very important role in cancer, aging, and other human diseases.Thus, the ability to measure the telomere length of individual cells is important for the study of cellular senescence, age-related diseases, and human development.
DNA Methylation Age AccelerationAge acceleration can be defined as the difference between the DNA methylation age and the actual age, or as the residual resulting from regressing the DNA methylation age on the actual age. In comparison, the latter definition is more accurate and practical. We can determine the rate of biological aging based on the specific value of the DNA methylation age acceleration, with positive values indicating faster than expected aging and negative values the opposite.DNA methylation age acceleration is closely related to the health status of the organism, aging-related diseases, mortality and other factors. On the one hand, several studies have identified DNA methylation age acceleration in age-related diseases, such as cancer, cardiovascular diseases, and neurodegenerative diseases. On the other hand, there are also some intrinsic and extrinsic factors that contribute to age acceleration in individuals, such as stress, alcohol consumption, smoking, etc.
Aging is a biological process that occurs in each of us as individuals and is accompanied by a variety of changes. At the molecular level, DNA methylation occurs, a process in which a methyl group is covalently bonded at the cytosine 5 carbon position of a genomic CpG dinucleotide, and the association between DNA methylation and aging has been extensively studied and their close correlation has been found.DNA methylation is an epigenetic modification that plays a key role in many aging-related biological processes. Based on this, we can use DNA methylation analysis for related studies, such as age prediction, disease risk prediction, and aging mechanism exploration.Longevity Interventions Evaluation Using DNA MethylationA number of interventions may be able to prevent age-related diseases and extend lifespan, including dietary, pharmacological and genetic, and the effects of interventions to delay aging and increase longevity can be assessed based on age-related DNA methylation changes.
ethylation-Based Biological Age and Cancer RiskChanges in DNA methylation levels with age, and it has been widely studied as a well-known biomarker of aging. A number of DNA methylation age clocks have appeared and been used, and when the age predicted by the methylation clock is greater than the actual age, it is considered to have "age acceleration", which is also called the biological measure of aging.Research suggests a correlation between aging and cancer as well. Predicted ages obtained by DNA methylation analysis are greater than actual ages, indicating age acceleration, and these phenomena may also be strongly associated with cancer risk. By analyzing the age acceleration of DNA methylation to discover their association with increased cancer risk or shorter survival, it could help to understand specific relationship between the aging process and cancer development, developing DNA methylation as a tool for predicting cancer risk.Application AreasGastric cancer researchLung cancer researchKidney cancer researchBreast cancer researchLymphoma researchRectal cancer research
The aging of today's global population is accelerating, leading to a higher incidence of some diseases related to aging, such as chronic diseases, neurodegenerative diseases, cardiovascular diseases, etc. However, people at the same age may show different disease expressions, and one possible factor is due to differences in the aging process of different individuals, which means that the actual age of individuals is the same but their biological age may be different.Then understanding the biological age and aging rate of different individuals, the latter is also known as age acceleration, can help us identify high incidence groups and is important for early disease prevention in aging research.
