What is Genetic Incorporation Services of Targeting Ligands?
To avoid the potential complexity of adaptor-based viral vector systems, researchers have developed genetic modifications to viral vectors involving the genetic incorporation of targeting ligands. Several research groups fuse the targeted ligand into the envelope protein or capsid of the viral vector to generate a single virion molecule that recognizes the target cell. While this strategy is technically challenging compared to adaptor-based approaches, this single-component systems allow for the production of homogenous retargeted viral vector particles. In addition to this, this strategy eliminates the need to design and develop separate adaptor molecules, facilitating the high-titer production of viral vectors in gene therapy of rare diseases.
