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Silica-based vectors are attractive as gene transfer vehicles due to their high stability, safety, and ease of structural and surface modification. A variety of silica-based vectors for gene delivery have been reported, including silica nanotubes (SNT), silica sheets, and silica NPs (solid (non-porous) silica NPs and porous silica NPs). Among these, silica NPs have been extensively investigated by researchers as carriers with many useful and attractive properties.Several reports have been publis...
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What is Genetic Incorporation Services of Targeting Ligands?To avoid the potential complexity of adaptor-based viral vector systems, researchers have developed genetic modifications to viral vectors involving the genetic incorporation of targeting ligands. Several research groups fuse the targeted ligand into the envelope protein or capsid of the viral vector to generate a single virion molecule that recognizes the target cell. While this strategy is technically challenging compared to adaptor-b...
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Introduction of The Cerebral CortexThe cerebral cortex is the outermost layer of tissue in the brain that is only a few millimeters thick. The appearance of the folds increase the surface area of the cerebral cortex, which contains between 14 billion and 16 billion neurons, thus allowing it to play an important role in human cognitive function, while controlling somatic movements and interpreting sensations.Injuries Caused by Cortical Function DeclineCerebral Cortex DisordersThe cerebral cortex,...
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Introduction to Genetic CircuitSynthetic biology is a field of science that deals with engineering and redesigning biological systems. The design of genetic circuits is inspired by electronics and computer science. Genetic circuits can perform logical functions mimicking those observed in electronic circuits and exhibit control over the flow of information in biological systems. Genetic circuit design should follow the principles of modularity, orthogonality, predictability, and reliability.In r...
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Telomere length is highly heterogeneous and varies with cell type, age, and individual. Most current measurements of telomere length use the average of cell populations. However, it is worth noting that methods to quantify the length of individual telomeres can provide valuable information about telomere length distribution.Telomere Length Measurement in Single Cells Extremely short telomeres are usually the cause of age-related pathology. The longest telomeres are markers of the adult stem cell...
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Biofilm Construction ServicesBacterial biofilm formation is a complex developmental process involving multiple stages, including migration and initial attachment, EPS production and irreversible attachment, maturation, disruption, and cell dispersion. In most environments, the mechanism of infection and pathogenesis is a continuous interaction between the host and the microorganism, as well as between the microorganisms themselves. These interactions can influence and determine the fate of infec...
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Turgor pressure measurement servicesTurgor pressure, also known as hydrostatic pressure, is the pressure on the cell wall generated by the expansion of a plant cell due to the volume of water absorbed. Turgor pressure is of physiological importance to plant growth. Not only does it maintain cellular tension and keep the plant in its natural posture, it also regulates the opening and closing of stomata. The growth of plant cells is thought to be the result of a finely tuned interaction between tu...
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High-performance liquid chromatography (HPLC) columns are used for the analysis or preparation of separated compounds from complex mixtures. The pressurized liquid solvent containing the sample mixture passes through a column filled with a solid adsorbent material. Since each component in the sample interacts with the adsorbent material slightly differently, the components with different flow rates are separated as they flow out of the column. According to separation mechanism, common HPLC colum...
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Samples superbug identificationBacteria are becoming resistant to antibiotics at an alarming rate, posing a major threat to our health care. Rapidly identifying the bacteria that cause specific infections is critical to preventing the development of antibiotic resistance. However, many researchers may face some challenging processes in superbug identification techniques.Rapid Detection of Superbugs Using PhagesPhages offer a unique opportunity for superbug detection. Using the ability of phages ...
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Introduction of TME biomarker detection servicesTumor markers appear along with tumors and are usually increased in amounts of proteins, oncogenes, tumor suppressor genes and their related products in the form of antigens, enzymes, receptors, hormones or metabolites. It is produced and secreted by tumor cells, or is part of the released tumor cell structure. It exists only in tumor cells and is often released into serum or other body fluids, which can reflect the presence of tumors in the body t...
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Cells play an important role in both pathological studies of stroke and in the development of therapies. In pathological studies, on the one hand, we provide a preliminary understanding of the pathological mechanisms of stroke by establishing different stroke models based on brain cells. On the other hand, we elaborate the role of stroke on different cells through the study of different cells in in vivo models. In therapeutic development, stem cell-based stroke therapy has been shown to be effec...
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Research on Psychiatric MechanismsMolecular biology analysis in psychiatry is an approach that relies on biological techniques at the molecular level to study psychiatric disorders. It includes the study of expression profiles, DNA, RNA, proteins, and metabolites at the molecular level.Our molecular biology analysis can also be applied to study the development of novel drugs. For example, by modulating one or more genes, proteins, and metabolic pathways to develop a novel drug and analyze its ef...
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Neoantigen is a kind of tumor-specific antigen derived from non-synonymous mutations, which plays an important role in the killing of tumor by immune cells, and effective anti-tumor immunity is directly related to tumor neoantigen-specific T cells. Neoantigens are highly immunogenic and specific, not expressed in normal tissues, and bypass the central thymus without immune tolerance, making them ideal targets for anti-tumor immunotherapy. With the development of next-generation sequencing techno...
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Background Metabolic rare diseases are diseases that result from some defect or abnormality in the metabolic process. These diseases are usually caused by genetic factors and affect the body's metabolic processes, such as protein, carbohydrate, and lipid metabolism. Metabolic rare diseases usually lead to serious health problems, including muscle wasting, liver disease, neurological damage, and more. Due to the rarity and complexity of these diseases, sophisticated research tools and techniques ...
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Exosomes are the smallest and most characteristic of extracellular vesicles and contain a variety of biological information, including proteins, lipids, DNA, mRNA, and microRNA. These biomolecules are involved in regulating various life activities such as signal transduction, proliferation, migration, and angiogenesis among tumor cells. Exosomes are not only a new biological marker assay, but also provide potential molecular therapeutic targets and are expected to be a carrier for anti-brain tum...
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Gene deletion is the process of removing one or more genes from an organism's genome. This technique is commonly used in genetic research to study the function of specific genes and their role in various biological processes like strain engineering. Gene deletion can be achieved through several methods, including CRISPR/Cas9 gene editing, homologous recombination, and transposon-mediated mutagenesis.Services for Gene DeletionOur gene deletion services are designed to help researchers study the f...
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Since the introduction of antibiotics, the bacteria they treat have been adapting and changing to become more resistant. These antibiotic-resistant bacteria are called superbugs, and they cause serious bacterial infections that are extremely difficult to treat. One of the key challenges in the fight against superbugs is the detection of drug-resistant bacteria. We offer low-cost, rapid detection tools and services for currently known or unknown drug-resistant pathogens.Different Types of Superbu...
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Cancer-Associated Fibroblasts (CAFs) Cancer-associated fibroblasts, or CAFs, are a type of stromal cell commonly found in the tumor microenvironment. They are associated with all stages of cancer and contribute to its progression in various ways. CAFs can increase the rate of cancer cell growth, promote the formation of new blood vessels, and facilitate the spread of cancer cells to other parts of the body.In addition to these effects, CAFs can also suppress the immune system's ability to fight ...
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Quantifying the resulting mechanical parameters is critical for clarifying the mechanical consequences caused by the changed cell wall composition. We are committed to providing our customers with services for the characterization of mechanical properties of plant cell walls and submitting detailed and scientific experimental reports to customers.Background of mechanical properties of cell wall analysis servicesThe cell wall has long been of interest to researchers because of its unique mechanic...
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Amerigo Scientific offers four series of ion exchange (IEX) chromatography resins of different matrix type and pore size to satisfy a variety of applications. These products are complementary with each other and are solutions of all process steps (capture, intermediate purification, and polishing) in chromatography for purifications of a variety of substances from small peptides to large proteins and viral particles.Uni Series IEX ResinsUniCM, UniSP, UniQ, UniDEAE, and UniMSP are designed for th...
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Radionuclide Drug Conjugate DesignRDC (Radionuclide Drug Conjugate) is an innovative and rapidly evolving multifunctional radiopharmaceutical. Composed of four components, including radionuclide, chelator, linker, and targeting molecule, RDC can accurately identify the diseased cells, image the binding cells, and damage the tumor.Bifunction of RDCDiagnostic ImagingNuclear imaging, providing detailed imaging at the molecular and cellular level, can accurately diagnose and analyze cancer. Both PET...
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Our company is a professional organization that provides animal behavior testing services to academic institutions and medical research facilities. We specialize in providing our customers with a wide range of classical motor behavior testing services to help them select the best research models and evaluation tools. We are pleased to apply our specialized testing services to our customers' movement disorder-related research to support their innovative research in related fields.Why Should I Con...
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Beam balance test is commonly used to assess motor coordination and balance in rodents. Our company, as a professional animal behavior testing organization, is committed to providing classical customized testing service solutions to customers worldwide, including beam balance test. The beam balance test we provide can accelerate customers' innovative research projects in brain injury, gene manipulation, and drug therapy.Experimental PrincipleThe beam balance test is used to test the balance abil...
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