Topic: biology

Biofilm is a complex, multi-dimensional spatial structure composed of microorganisms and their extracellular polymers adhered to the surface of living or non-living bodies, and is ubiquitous in nature. Biofilms are increasingly detected in patients with infectious diseases or in animal models. The relationship between the formation of biofilm and infectious diseases and its role in the occurrence, development and prognosis of diseases have become a hot research topic in recent years. At present,...

IntroductionAging is a biological process that occurs in each of us as individuals and is accompanied by a variety of changes. At the molecular level, DNA methylation occurs, a process in which a methyl group is covalently bonded at the cytosine 5 carbon position of a genomic CpG dinucleotide, and the association between DNA methylation and aging has been extensively studied and their close correlation has been found.DNA methylation is an epigenetic modification that plays a key role in many agi...

Ace Neuroscience is committed to supporting scientists in making groundbreaking scientific discoveries and developing new applications to accelerate drug discovery and scientific diagnosis and treatment of antipsychotic diseases. We have a mature animal model research and development platform. We aim to provide customized services for animal models of depression for psychiatric research and to help researchers successfully achieve their research goals.Introduction of Animal Models in PsychiatryN...

Beam balance test is commonly used to assess motor coordination and balance in rodents. Our company, as a professional animal behavior testing organization, is committed to providing classical customized testing service solutions to customers worldwide, including beam balance test. The beam balance test we provide can accelerate customers' innovative research projects in brain injury, gene manipulation, and drug therapy.Experimental PrincipleThe beam balance test is used to test the balance abil...

Our company is a professional organization that provides animal behavior testing services to academic institutions and medical research facilities. We specialize in providing our customers with a wide range of classical motor behavior testing services to help them select the best research models and evaluation tools. We are pleased to apply our specialized testing services to our customers' movement disorder-related research to support their innovative research in related fields.Why Should I Con...

Exosomes are the smallest and most characteristic of extracellular vesicles and contain a variety of biological information, including proteins, lipids, DNA, mRNA, and microRNA. These biomolecules are involved in regulating various life activities such as signal transduction, proliferation, migration, and angiogenesis among tumor cells. Exosomes are not only a new biological marker assay, but also provide potential molecular therapeutic targets and are expected to be a carrier for anti-brain tum...

Neoantigen is a kind of tumor-specific antigen derived from non-synonymous mutations, which plays an important role in the killing of tumor by immune cells, and effective anti-tumor immunity is directly related to tumor neoantigen-specific T cells. Neoantigens are highly immunogenic and specific, not expressed in normal tissues, and bypass the central thymus without immune tolerance, making them ideal targets for anti-tumor immunotherapy. With the development of next-generation sequencing techno...

Introduction of TME biomarker detection servicesTumor markers appear along with tumors and are usually increased in amounts of proteins, oncogenes, tumor suppressor genes and their related products in the form of antigens, enzymes, receptors, hormones or metabolites. It is produced and secreted by tumor cells, or is part of the released tumor cell structure. It exists only in tumor cells and is often released into serum or other body fluids, which can reflect the presence of tumors in the body t...

Research on Psychiatric MechanismsMolecular biology analysis in psychiatry is an approach that relies on biological techniques at the molecular level to study psychiatric disorders. It includes the study of expression profiles, DNA, RNA, proteins, and metabolites at the molecular level.Our molecular biology analysis can also be applied to study the development of novel drugs. For example, by modulating one or more genes, proteins, and metabolic pathways to develop a novel drug and analyze its ef...

Cells play an important role in both pathological studies of stroke and in the development of therapies. In pathological studies, on the one hand, we provide a preliminary understanding of the pathological mechanisms of stroke by establishing different stroke models based on brain cells. On the other hand, we elaborate the role of stroke on different cells through the study of different cells in in vivo models. In therapeutic development, stem cell-based stroke therapy has been shown to be effec...

High-performance liquid chromatography (HPLC) columns are used for the analysis or preparation of separated compounds from complex mixtures. The pressurized liquid solvent containing the sample mixture passes through a column filled with a solid adsorbent material. Since each component in the sample interacts with the adsorbent material slightly differently, the components with different flow rates are separated as they flow out of the column. According to separation mechanism, common HPLC colum...

Turgor pressure measurement servicesTurgor pressure, also known as hydrostatic pressure, is the pressure on the cell wall generated by the expansion of a plant cell due to the volume of water absorbed. Turgor pressure is of physiological importance to plant growth. Not only does it maintain cellular tension and keep the plant in its natural posture, it also regulates the opening and closing of stomata. The growth of plant cells is thought to be the result of a finely tuned interaction between tu...

Biofilm Construction ServicesBacterial biofilm formation is a complex developmental process involving multiple stages, including migration and initial attachment, EPS production and irreversible attachment, maturation, disruption, and cell dispersion. In most environments, the mechanism of infection and pathogenesis is a continuous interaction between the host and the microorganism, as well as between the microorganisms themselves. These interactions can influence and determine the fate of infec...

Telomere length is highly heterogeneous and varies with cell type, age, and individual. Most current measurements of telomere length use the average of cell populations. However, it is worth noting that methods to quantify the length of individual telomeres can provide valuable information about telomere length distribution.Telomere Length Measurement in Single Cells Extremely short telomeres are usually the cause of age-related pathology. The longest telomeres are markers of the adult stem cell...

Introduction to Genetic CircuitSynthetic biology is a field of science that deals with engineering and redesigning biological systems. The design of genetic circuits is inspired by electronics and computer science. Genetic circuits can perform logical functions mimicking those observed in electronic circuits and exhibit control over the flow of information in biological systems. Genetic circuit design should follow the principles of modularity, orthogonality, predictability, and reliability.In r...

Introduction of The Cerebral CortexThe cerebral cortex is the outermost layer of tissue in the brain that is only a few millimeters thick. The appearance of the folds increase the surface area of the cerebral cortex, which contains between 14 billion and 16 billion neurons, thus allowing it to play an important role in human cognitive function, while controlling somatic movements and interpreting sensations.Injuries Caused by Cortical Function DeclineCerebral Cortex DisordersThe cerebral cortex,...

Silica-based vectors are attractive as gene transfer vehicles due to their high stability, safety, and ease of structural and surface modification. A variety of silica-based vectors for gene delivery have been reported, including silica nanotubes (SNT), silica sheets, and silica NPs (solid (non-porous) silica NPs and porous silica NPs). Among these, silica NPs have been extensively investigated by researchers as carriers with many useful and attractive properties.Several reports have been publis...

Introduction to Protein DesignProtein design aims to create proteins with enhanced or novel activity, behavior, or other functional properties. As a powerful tool, it may have a profound impact on synthetic biology and may have more rapid and innovative applications. In the near future, protein design, especially computational design, will greatly expand the functional capabilities of synthetic cells. De Novo Protein DesignIn de novo protein design, the ultimate objective is to identify the appr...

DNA Methylation Age AccelerationAge acceleration can be defined as the difference between the DNA methylation age and the actual age, or as the residual resulting from regressing the DNA methylation age on the actual age. In comparison, the latter definition is more accurate and practical. We can determine the rate of biological aging based on the specific value of the DNA methylation age acceleration, with positive values indicating faster than expected aging and negative values the opposite.DN...

Laboratory equipment is a general term for the various instruments, containers and other tools needed for operation, synthesis, and analysis in various laboratories. The equipment helps researchers to observe, test, experiment or analyze data to confirm the authenticity or rationality of scientific hypotheses. According to the scope of application, laboratory equipment can be divided into general equipment and specialized equipment.General laboratory equipment includes freezers, incubators, shak...

Strong base anion (SBA) exchange resin is one type of ion exchange resins containing quaternary ammonium groups on the microsphere surfaces. The SBA resin shows an excellent physical and chemical stability, which is capable to exchange the different anion under a wide range of pH value. SBA resins are ideal for removing certain anionic contaminants and can be regenerated with salt.SBA resins are usually divided into two classes according to their functional groups. Type I SBA resins are aminated...

Aging is a biological process that occurs in each of us as individuals and is accompanied by a variety of changes. At the molecular level, DNA methylation occurs, a process in which a methyl group is covalently bonded at the cytosine 5 carbon position of a genomic CpG dinucleotide, and the association between DNA methylation and aging has been extensively studied and their close correlation has been found.DNA methylation is an epigenetic modification that plays a key role in many aging-related b...

The ability to overexpress genes in microorganisms has revolutionized the field of synthetic biology. Gene overexpression involves the production of large quantities of target proteins by increasing the transcription and translation of the gene of interest. This technique has been applied in the engineering of microorganisms to produce a wide range of products, including biofuels, chemicals, and biopharmaceuticals. There are several strategies for gene overexpression in strain engineering. One c...

In the field of scientific research, understanding and studying emotion-related behaviors in animals plays a crucial role in advancing the knowledge of the human brain and mental health. Animal models can help researchers better comprehend animal behaviors, and rodent models in particular have become important objects for understanding the mechanisms of emotional behaviors and exploring new treatments for emotion-related disorders including anxiety, depression, and stress. With their remarkable ...

The diagnosis and treatment of rare diseases have long been a daunting challenge due to their complex and often undefined nature. However, with recent advancements in technology, specifically in the realm of genomics, whole genome sequencing (WGS) has emerged as a powerful tool that has revolutionized the diagnosis and management of rare diseases. This groundbreaking technique offers hope to countless individuals and their families who have suffered from the uncertainties and lack of answers ass...