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Background Metabolic rare diseases are diseases that result from some defect or abnormality in the metabolic process. These diseases are usually caused by genetic factors and affect the body's metabolic processes, such as protein, carbohydrate, and lipid metabolism. Metabolic rare diseases usually lead to serious health problems, including muscle wasting, liver disease, neurological damage, and more. Due to the rarity and complexity of these diseases, sophisticated research tools and techniques ...
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Exosomes are the smallest and most characteristic of extracellular vesicles and contain a variety of biological information, including proteins, lipids, DNA, mRNA, and microRNA. These biomolecules are involved in regulating various life activities such as signal transduction, proliferation, migration, and angiogenesis among tumor cells. Exosomes are not only a new biological marker assay, but also provide potential molecular therapeutic targets and are expected to be a carrier for anti-brain tum...
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Neoantigen is a kind of tumor-specific antigen derived from non-synonymous mutations, which plays an important role in the killing of tumor by immune cells, and effective anti-tumor immunity is directly related to tumor neoantigen-specific T cells. Neoantigens are highly immunogenic and specific, not expressed in normal tissues, and bypass the central thymus without immune tolerance, making them ideal targets for anti-tumor immunotherapy. With the development of next-generation sequencing techno...
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Introduction of TME biomarker detection servicesTumor markers appear along with tumors and are usually increased in amounts of proteins, oncogenes, tumor suppressor genes and their related products in the form of antigens, enzymes, receptors, hormones or metabolites. It is produced and secreted by tumor cells, or is part of the released tumor cell structure. It exists only in tumor cells and is often released into serum or other body fluids, which can reflect the presence of tumors in the body t...
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Research on Psychiatric MechanismsMolecular biology analysis in psychiatry is an approach that relies on biological techniques at the molecular level to study psychiatric disorders. It includes the study of expression profiles, DNA, RNA, proteins, and metabolites at the molecular level.Our molecular biology analysis can also be applied to study the development of novel drugs. For example, by modulating one or more genes, proteins, and metabolic pathways to develop a novel drug and analyze its ef...
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Cells play an important role in both pathological studies of stroke and in the development of therapies. In pathological studies, on the one hand, we provide a preliminary understanding of the pathological mechanisms of stroke by establishing different stroke models based on brain cells. On the other hand, we elaborate the role of stroke on different cells through the study of different cells in in vivo models. In therapeutic development, stem cell-based stroke therapy has been shown to be effec...
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Samples superbug identificationBacteria are becoming resistant to antibiotics at an alarming rate, posing a major threat to our health care. Rapidly identifying the bacteria that cause specific infections is critical to preventing the development of antibiotic resistance. However, many researchers may face some challenging processes in superbug identification techniques.Rapid Detection of Superbugs Using PhagesPhages offer a unique opportunity for superbug detection. Using the ability of phages ...
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High-performance liquid chromatography (HPLC) columns are used for the analysis or preparation of separated compounds from complex mixtures. The pressurized liquid solvent containing the sample mixture passes through a column filled with a solid adsorbent material. Since each component in the sample interacts with the adsorbent material slightly differently, the components with different flow rates are separated as they flow out of the column. According to separation mechanism, common HPLC colum...
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Turgor pressure measurement servicesTurgor pressure, also known as hydrostatic pressure, is the pressure on the cell wall generated by the expansion of a plant cell due to the volume of water absorbed. Turgor pressure is of physiological importance to plant growth. Not only does it maintain cellular tension and keep the plant in its natural posture, it also regulates the opening and closing of stomata. The growth of plant cells is thought to be the result of a finely tuned interaction between tu...
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Biofilm Construction ServicesBacterial biofilm formation is a complex developmental process involving multiple stages, including migration and initial attachment, EPS production and irreversible attachment, maturation, disruption, and cell dispersion. In most environments, the mechanism of infection and pathogenesis is a continuous interaction between the host and the microorganism, as well as between the microorganisms themselves. These interactions can influence and determine the fate of infec...
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Telomere length is highly heterogeneous and varies with cell type, age, and individual. Most current measurements of telomere length use the average of cell populations. However, it is worth noting that methods to quantify the length of individual telomeres can provide valuable information about telomere length distribution.Telomere Length Measurement in Single Cells Extremely short telomeres are usually the cause of age-related pathology. The longest telomeres are markers of the adult stem cell...
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Introduction to Genetic CircuitSynthetic biology is a field of science that deals with engineering and redesigning biological systems. The design of genetic circuits is inspired by electronics and computer science. Genetic circuits can perform logical functions mimicking those observed in electronic circuits and exhibit control over the flow of information in biological systems. Genetic circuit design should follow the principles of modularity, orthogonality, predictability, and reliability.In r...
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